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Dataset Intersectionality

Gut Reaction brings together high quality, curated and interlinked data sets from different sources

Gut Reaction facilitates access to various data sources, supporting innovative research in IBD. Building on the information available in the NIHR BioResource, researchers can request access to a broad range of demographic, lifestyle, genetic and clinical information. Our datasets present a high degree of overlap, offering a rich data source for research.

 

Details of the overlap between the currently available datasets can be found below (last updated December 2022)

Core NIHR BioResource datasets

Data linkage between core NIHR BioResource datasets*

Venn diagram showing the high degree of overlap between datasets; the intersections show the total number of participants available within each category, with demographic and contact details available for nearly 97% of participants (Dec-22).

*Demographic data includes age or age bands, gender, ethnicity, weight, height, BMI, dietary habits, hand preference, alcohol consumption, smoking status and hand dominance.

Core NIHR BioResource datasets, plus genotype and study forms

Data linkage between core NIHR BioResource datasets, plus genotype and study forms**

Overlap between the core datasets (consent and demographics) and the datasets derived from study forms (CRF and HLQ) and genotype. Of the fully-consented population, almost all have case report forms and demographic data available; just under two thirds also have a valid health and lifestyle questionnaire.

**Study forms include the Clinical case report form (CRF) and the Health and lifestyle questionnaire (HLQ).

Core NIHR BioResource datasets, genotype and samples

Data linkage between core NIHR BioResource datasets, NHS Trust data#, samples## and genotype###

Overlap between the core datasets (consent and demographics) and the datasets derived from NHS Trust data, samples and genotype. This shows the high degree of overlap between categories; genotyping data is available for in excess of 16,000 consented individuals.

#NHS Trust data includes participant clinical data such as test results, clinical letters and correspondence, diagnoses data, discharge records from hospitals, and radiography/pathology images taken in Trusts;

##genetic sample tested on single nucleotide polymorphisms (SNP), and statistical inference imputation;
###blood, serum or DNA

Core NIHR BioResource participants, genotyping, samples and forms

Data linkage between core NIHR BioResource datasets, genotyping and study forms

Overlap between the core datasets (consent and demographics) and the datasets derived from genotype and study forms show that genotyping data is available for in excess of 16,000 consented individuals. Nearly 36% of consented participants (13,989) have all six datasets available, providing a rich data source for approved researchers

Data links